Effects of a single aerobic exercise on perfused boundary region and microvascular perfusion: a field study.

Fuchs A, Neumann T, Drinhaus H, Herrmann A, Vink H, Annecke T.
​J Clin Monit Comput. 2022 Apr;36(2):371-377.

Cerebrovascular glycocalyx damage and microcirculation impairment in patients with temporal lobe epilepsy.

van Lanen RH, Haeren RH, Staals J, Dings JT, Schijns OE, Hoogland G, van Kuijk SM, Kapsokalyvas D, van Zandvoort MA, Vink H, Rijkers K.
​J Cereb Blood Flow Metab. 2023 Oct;43(10):1737-1751

Immediate effects of whole blood donation on the endothelial surface layer and glycocalyx shedding.

Fuchs A, Groß S, Neumann T, Illerhaus A, Vink H, Klasen G, Gathof B, Annecke T.
​Blood Transfus. 2021 May;19(3):190-196

Glomerular Function and Structural Integrity Depend on Hyaluronan Synthesis by Glomerular Endothelium.

van den Berg BM, Wang G, Boels MGS, Avramut MC, Jansen E, Sol WMPJ, Lebrin F, van Zonneveld AJ, de Koning EJP, Vink H, Gröne HJ, Carmeliet P, van der Vlag J, Rabelink TJ. J Am Soc Nephrol. 2019 Oct;30(10):1886-1897

Damage of the endothelial glycocalyx in dialysis patients.

Vlahu CA, Lemkes BA, Struijk DG, Koopman MG, Krediet RT, Vink H.
J Am Soc Nephrol. 2012 Nov;23(11):

A Dietary Supplement Containing Fucoidan Preserves Endothelial Glycocalyx through ERK/MAPK Signaling and Protects against Damage Induced by CKD Serum.

Regier M, Drost CC, Rauen M, Pavenstädt H, Rovas A, Kümpers P, Vink H, Long RM, Linke WA, Nofer JR, Lukasz AH. Int J Mol Sci. 2022 Dec 8;23(24):15520

Non-invasive assessment of microvascular dysfunc-tion in patients with microvascular angina.

Jaarsma C, Vink H, van Haare J, Bekkers SCAM, van Rooijen BD, Backes WH, Wildberger JE, Crijns HJ, van Teeffelen J, Schalla S. Int J Cardiol. 2017 Dec 1;248:433-439

Heparan sulfate mimetic fucoidan restores the endothelial glycocalyx and protects against dysfunction induced by serum of COVID-19 patients in the intensive care unit.

Yuan L, Cheng S, Sol WMPJ, van der Velden AIM, Vink H, Rabelink TJ, van den Berg BM. ERJ Open Res. 2022 May 3;8(2):00652-2021

Uncoupling of Microvascular Blood Flow and Capillary Density in Vascular Cognitive Impairment.

Zhang CE, Staals J, van Oostenbrugge RJ, Vink H. Front Neurol. 2019 Dec 3;10:1268

Association of sublingual microcirculation para-meters and endothelial glycocalyx dimensions in resuscitated sepsis.

Rovas A, Seidel LM, Vink H, Pohlkötter T, Pavenstädt H, Ertmer C, Hessler M, Kümpers P. Crit Care. 2019 Jul 24;23(1):260

Mechanotransduction and flow across the endothelial glycocalyx.

Weinbaum S, Zhang X, Han Y, Vink H, Cowin SC. Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7988-95.

Non-invasive assessment of microvascular dys-function in families with premature coronary artery disease.

Mulders TA, Nieuwdorp M, Stroes ES, Vink H, Pinto-Sietsma SJ. ​Int J Cardiol. 2013 Oct 12;168(5):5026-8.

Acute ischemic injury to the renal microvasculature in human kidney transplan-tation.

Snoeijs MG, Vink H, Voesten N, Christiaans MH, Daemen JW, Peppelenbosch AG, Tordoir JH, Peutz-Kootstra CJ, Buurman WA, Schurink GW, van Heurn LW. Am J Physiol Renal Physiol. 2010 Nov;299(5):F1134-40.

Citrulline a more suitable substrate than arginine to restore NO production and the microcirculation during endotoxemia.

Wijnands KA, Vink H, Briedé JJ, van Faassen EE, Lamers WH, Buurman WA, Poeze M. PLoS One. 2012;7(5):e37439.

Association of kidney function with changes in the endothelial surface layer.

Dane MJ, Khairoun M, Lee DH, van den Berg BM, Eskens BJ, Boels MG, van Teeffelen JW, Rops AL, van der Vlag J, van Zonneveld AJ, Reinders ME, Vink H, Rabelink TJ. Clin J Am Soc Nephrol. 2014 Apr;9(4):698-704

Glomerular endothelial surface layer acts as a barrier against albumin filtration.

Dane MJ, van den Berg BM, Avramut MC, Faas FG, van der Vlag J, Rops AL, Ravelli RB, Koster BJ, van Zonneveld AJ, Vink H, Rabelink TJ. Am J Pathol. 2013 May;182(5):1532-40.

Early impairment of coronary microvascular perfusion capacity in rats on a high fat diet.

Early impairment of coronary microvascular perfusion capacity in rats on a high fat diet.
van Haare J, Kooi ME, Vink H, Post MJ, van Teeffelen JW, Slenter J, Munts C, Cobelens H, Strijkers GJ, Koehn D, van Bilsen M. Cardiovasc Diabetol. 2015 Nov 17;14:150.

Capillary blood volume increase in already perfused capillaries: role for glycocalyx modulation.

Van Teeffelen J, Vink H.
J Appl Physiol (1985). 2008 Mar;104(3):895.

Visual and Biochemical Evidence of Glycocalyx Disruption in Human Dengue Infection, and Association With Plasma Leakage Severity.

Lam PK, McBride A, Le DHT, Huynh TT, Vink H, Wills B, Yacoub S. Front Med (Lausanne). 2020 Oct 16;7:545813.

Effects of ultrapure hemodialysis and low molecular weight heparin on the endothelial surface layer.

Cornelis T, Broers NJ, Titulaer DC, Henskens YM, van Oerle R, van der Sande FM, Spronk HM, Vink H, Leunissen KM, ten Cate H, Kooman JP.
Blood Purif. 2014;38(3-4):203-10.

Side-by-Side Alterations in Glycocalyx Thickness and Perfused Microvascular Density During Acute Microcirculatory Alterations in Cardiac Surgery.

Koning NJ, Vonk AB, Vink H, Boer C.
Microcirculation. 2016 Jan;23(1):69-74.

Bedside analysis of the sublingual microvascular glycocalyx in the emergency room and intensive care unit - the GlycoNurse study.

Rovas A, Lukasz AH, Vink H, Urban M, Sackarnd J, Pavenstädt H, Kümpers P.
​Scand J Trauma Resusc Emerg Med. 2018 Feb 14;26(1):16.

Effects of two weeks of metformin treatment on whole-body glycocalyx barrier properties in db/db mice.

Eskens BJ, Zuurbier CJ, van Haare J, Vink H, van Teeffelen JW. Cardiovasc Diabetol. 2013 Dec 5;12:175.

Fluid shear stress stimulates incorporation of hyaluronan into endothelial cell glycocalyx.

Gouverneur M, Spaan JA, Pannekoek H, Fontijn RD, Vink H. Am J Physiol Heart Circ Physiol. 2006 Jan;290(1):H458-2.

Endothelial cell glycocalyx modulates immobilization of leukocytes at the endothelial surface.

Constantinescu AA, Vink H, Spaan JA.
Arterioscler Thromb Vasc Biol. 2003 Sep 1;23(9):1541-7.

Heparin impairs glycocalyx barrier properties and attenuates shear dependent vasodilation in mice.

Heparin impairs glycocalyx barrier properties and attenuates shear dependent vasodilation in mice.
VanTeeffelen JW, Brands J, Jansen C, Spaan JA, Vink H. Hypertension. 2007 Jul;50(1):261-7.

Whole-body recruitment of glycocalyx volume during intravenous adenosine infusion

rands J, van Haare J, Vink H, Vanteeffelen JW. ​Physiol Rep. 2013 Oct;1(5):e00102.

Measuring endothelial glycocalyx dimensions in humans: a potential novel tool to monitor vascular vulnerability

Nieuwdorp M, Meuwese MC, Mooij HL, Ince C, Broekhuizen LN, Kastelein JJ, Stroes ES, Vink H. ​J Appl Physiol (1985). 2008 Mar;104(3):845-52.

Skeletal muscle capillary density and microvascular function are compromised with aging and type 2 diabetes

Groen BB, Hamer HM, Snijders T, van Kranenburg J, Frijns D, Vink H, van Loon LJ. J Appl Physiol (1985). 2014 Apr 15;116(8):998-1005

Comparison of four mathematical models to analyze indicator-dilution curves in the coronary circulation

Brands J, Vink H, Van Teeffelen JW.
Med Biol Eng Comput. 2011 Dec;49(12):1471-9.

Side-by-Side Alterations in Glycocalyx Thickness and Perfused Microvascular Density During Acute Microcirculatory Alterations in Cardiac Surgery.

Koning NJ, Vonk AB, Vink H, Boer C.
Microcirculation. 2016 Jan;23(1):69-74.

Bedside analysis of the sublingual microvascular glycocalyx in the emergency room and intensive care unit - the GlycoNurse study.

Rovas A, Lukasz AH, Vink H, Urban M, Sackarnd J, Pavenstädt H, Kümpers P.
​Scand J Trauma Resusc Emerg Med. 2018 Feb 14;26(1):16.

Effects of two weeks of metformin treatment on whole-body glycocalyx barrier properties in db/db mice.

Eskens BJ, Zuurbier CJ, van Haare J, Vink H, van Teeffelen JW. Cardiovasc Diabetol. 2013 Dec 5;12:175.

Fluid shear stress stimulates incorporation of hyaluronan into endothelial cell glycocalyx.

Gouverneur M, Spaan JA, Pannekoek H, Fontijn RD, Vink H. Am J Physiol Heart Circ Physiol. 2006 Jan;290(1):H458-2.

Endothelial cell glycocalyx modulates immobilization of leukocytes at the endothelial surface.

Constantinescu AA, Vink H, Spaan JA.
Arterioscler Thromb Vasc Biol. 2003 Sep 1;23(9):1541-7.

Heparin impairs glycocalyx barrier properties and attenuates shear dependent vasodilation in mice.

Heparin impairs glycocalyx barrier properties and attenuates shear dependent vasodilation in mice.
VanTeeffelen JW, Brands J, Jansen C, Spaan JA, Vink H. Hypertension. 2007 Jul;50(1):261-7.

Whole-body recruitment of glycocalyx volume during intravenous adenosine infusion

rands J, van Haare J, Vink H, Vanteeffelen JW. ​Physiol Rep. 2013 Oct;1(5):e00102.

Measuring endothelial glycocalyx dimensions in humans: a potential novel tool to monitor vascular vulnerability

Nieuwdorp M, Meuwese MC, Mooij HL, Ince C, Broekhuizen LN, Kastelein JJ, Stroes ES, Vink H. ​J Appl Physiol (1985). 2008 Mar;104(3):845-52.

Skeletal muscle capillary density and microvascular function are compromised with aging and type 2 diabetes

Groen BB, Hamer HM, Snijders T, van Kranenburg J, Frijns D, Vink H, van Loon LJ. J Appl Physiol (1985). 2014 Apr 15;116(8):998-1005

Comparison of four mathematical models to analyze indicator-dilution curves in the coronary circulation

Brands J, Vink H, Van Teeffelen JW.
Med Biol Eng Comput. 2011 Dec;49(12):1471-9.

Microrheology of hyaluronan solutions: implications for the endothelial glycocalyx

Nijenhuis N, Mizuno D, Schmidt CF, Vink H, Spaan JA.Biomacromolecules. 2008 Sep;9(9):2390-8.

Hypercholesterolemia impairs reactive hyperemic vasodilation of 2A but not 3A arterioles in mouse cremaster muscle

VanTeeffelen JW, Constantinescu AA, Vink H, Spaan JA. Am J Physiol Heart Circ Physiol. 2005 Jul;289(1):H447-54.

Atherogenic region and diet diminish glycocalyx dimension and increase intima-to-media ratios at murine carotid artery bifurcation

van den Berg BM, Spaan JA, Rolf TM, Vink H. Am J Physiol Heart Circ Physiol. 2006 Feb;290(2):H915-20.

Endothelial glycocalyx dimensions are reduced in growing collateral arteries and modulate leucocyte adhesion in arteriogenesis

Grundmann S, Schirmer SH, Hekking LH, Post JA, Ionita MG, de Groot D, van Royen N, van den Berg B, Vink H, Moser M, Bode C, de Kleijn D, Pasterkamp G, Piek JJ, Hoefer IE. J Cell Mol Med. 2009 Sep;13(9B):3463-74.

Localization of the permeability barrier to solutes in isolated arteries by confocal microscopy

van Haaren PM, VanBavel E, Vink H, Spaan JA. Am J Physiol Heart Circ Physiol. 2003 Dec;285(6):H2848-56.

Endothelial surface layer degradation by chronic hyaluronidase infusion induces proteinuria in apolipoprotein E-deficient mice

Meuwese MC, Broekhuizen LN, Kuikhoven M, Heeneman S, Lutgens E, Gijbels MJ, Nieuwdorp M, Peutz CJ, Stroes ES, Vink H, van den Berg BM.
PLoS One. 2010 Dec 8;5(12):e14262.

Reduction of monocyte chemoattractant protein 1 and macrophage migration inhibitory factor by a polyphenol-rich extract in subjects with clustered cardiometabolic risk factors

Broekhuizen LN, van Wijk DF, Vink H, Stalmach A, Crozier A, Hutten BA, Kastelein JJ, Hugenholtz PG, Koenig W, Stroes ES. Br J Nutr. 2011 Nov;106(9):1416-22.

Short-term hyperglycemia increases endothelial glycocalyx permeability and acutely decreases lineal density of capillaries with flowing red blood cells

Zuurbier CJ, Demirci C, Koeman A, Vink H, Ince C. J Appl Physiol (1985). 2005 Oct;99(4):1471-6.

Microcirculatory effects of the transfusion of leukodepleted or non-leukodepleted red blood cells in patients with sepsis: a pilot study

Donati A, Damiani E, Luchetti M, Domizi R, Scorcella C, Carsetti A, Gabbanelli V, Carletti P, Bencivenga R, Vink H, Adrario E, Piagnerelli M, Gabrielli A, Pelaia P, Ince C. Crit Care. 2014 Feb 17;18(1):R33.

Bradykinin- and sodium nitroprusside-induced increases in capillary tube haematocrit in mouse cremaster muscle are associated with impaired glycocalyx barrier properties

VanTeeffelen JW, Constantinescu AA, Brands J, Spaan JA, Vink H.
J Physiol. 2008 Jul 1;586(13):3207-18.

Hyaluronidase treatment of coronary glycocalyx increases reactive hyperemia but not adenosine hyperemia in dog hearts

VanTeeffelen JW, Dekker S, Fokkema DS, Siebes M, Vink H, Spaan JA.
​Am J Physiol Heart Circ Physiol. 2005 Dec;289(6):H2508-13.

Charge modification of the endothelial surface layer modulates the permeability barrier of isolated rat mesenteric small arteries

van Haaren PM, VanBavel E, Vink H, Spaan JA. Am J Physiol Heart Circ Physiol. 2005 Dec;289(6):H2503-7