Groundbreaking Glycocalyx Discoveries by the Glycocalyx Research Institute

Watch Our Video Overview about the Glycocalyx and the Glycocalyx Research Institute

The Transparent Microscopic Lining of Capillaries, Veins and Arteries

The Endothelial Glycocalyx is a Gel-like Layer at the Luminal Side of Endothelial Cells Lining the Blood Vessels Throughout the Body.

Video of microvascular (microscopic capillary) blood flow captured by the GlycoCheck™ camera.

35

Years of Research and Development on the Glycocalyx

10,000

Square Feet of Glycocalyx: The Largest Surface Area of Any Organ

60,000

Miles of
Glycocalyx: The Longest Organ in the Body

16,000

Citations Worldwide Verifying Glycocalyx Role

The Glycocalyx

The original black and white images of the glycocalyx above were colorized to provide greater detail and clarity. Colorization helps to distinguish various structures and components within the glycocalyx, making it easier to identify and analyze specific features

The glycocalyx, a complex layer of sugars and proteins coating the inner surface of blood vessels, plays a critical role in the health of cells, tissues, and organs through its influence on microcirculation. Microcirculation refers to the flow of blood through the smallest vessels in the body, the capillaries, which are crucial for delivering nutrients and oxygen to cells and removing waste products.

A Healthy vs Unhealthy Glycocalyx

The original black and white images of the glycocalyx above were colorized to provide greater detail and clarity. Colorization helps to distinguish various structures and components within the glycocalyx, making it easier to identify and analyze specific features

When the glycocalyx is healthy, it ensures efficient and smooth blood flow through capillaries, which make up 99% of the body's total circulatory system.

This optimal blood flow allows for the effective delivery of nutrients and oxygen to every cell and aids in the removal of toxins and waste products. Consequently, the cells, tissues, and organs maintain their health and function properly.

However, if the glycocalyx becomes damaged or compromised, this negatively impacts the microcirculation. The damaged glycocalyx leads to impaired capillary function, where blood flow is restricted or altered.

This reduction in microcirculation means that cells receive less oxygen and nutrients, and the removal of toxic waste products is hindered.

​Over time, this can contribute to the development of various diseases, as cells and tissues are unable to function optimally due to the lack of essential supplies and the buildup of harmful substances.

The Micro Vascular System 

Microscopic capillaries, making up 99% of our circulatory system, are essential for distributing oxygen and nutrients and eliminating toxins from the body. However, when the glycocalyx is impaired, this crucial capillary circulation is reduced, leading to the deterioration of cells, tissues, and organs, which can result in numerous diseases and eventual death.

Groundbreaking Glycocalyx Discoveries by the Glycocalyx Research Institute

Watch Our Video Overview about the Glycocalyx and the Glycocalyx Research Institute

The Transparent Microscopic Lining of Capillaries, Veins and Arteries

The Endothelial Glycocalyx is a Gel-like Layer at the Luminal Side of Endothelial Cells
Lining the Blood Vessels Throughout the Body.

Video of microvascular (microscopic capillary) blood flow captured by the GlycoCheck™ camera.

35

Years of Research and Development on the Glycocalyx

10,000

Square Feet of Glycocalyx: The Largest Surface Area of Any Organ

60,000

Miles of
Glycocalyx: The Longest Organ in the Body

16,000

Citations Worldwide Verifying Glycocalyx Role

The Glycocalyx

The original black and white images of the glycocalyx above were colorized to provide greater detail and clarity. Colorization helps to distinguish various structures and components within the glycocalyx, making it easier to identify and analyze specific features

The original black and white images of the glycocalyx above were colorized to provide greater detail and clarity. Colorization helps to distinguish various structures and components within the glycocalyx, making it easier to identify and analyze specific features

Cross-section of a capillary blood vessel shows extensive dimension of the glycocalyx in a healthy blood vessel.

High magnification showing the dimension of the glycocalyx's several fold thickness of the endothelium.

Cross-section of a capillary blood vessel shows extensive dimension of the glycocalyx in a healthy blood vessel.

High magnification showing the dimension of the glycocalyx's several fold thickness of the endothelium.

The glycocalyx, a complex layer of sugars and proteins coating the inner surface of blood vessels, plays a critical role in the health of cells, tissues, and organs through its influence on microcirculation. Microcirculation refers to the flow of blood through the smallest vessels in the body, the capillaries, which are crucial for delivering nutrients and oxygen to cells and removing waste products.

A Healthy vs Unhealthy Glycocalyx

The original black and white images of the glycocalyx above were colorized to provide greater detail and clarity. Colorization helps to distinguish various structures and components within the glycocalyx, making it easier to identify and analyze specific features

Healthy Glycocalyx

Unhealthy Glycocalyx

When the glycocalyx is healthy, it ensures efficient and smooth blood flow through capillaries, which make up 99% of the body's total circulatory system.

This optimal blood flow allows for the effective delivery of nutrients and oxygen to every cell and aids in the removal of toxins and waste products. Consequently, the cells, tissues, and organs maintain their health and function properly.

However, if the glycocalyx becomes damaged or compromised, this negatively impacts the microcirculation. The damaged glycocalyx leads to impaired capillary function, where blood flow is restricted or altered.

This reduction in microcirculation means that cells receive less oxygen and nutrients, and the removal of toxic waste products is hindered.

​Over time, this can contribute to the development of various diseases, as cells and tissues are unable to function optimally due to the lack of essential supplies and the buildup of harmful substances.

Early Signs of Endothelial
​Glycocalyx Dysfunction

The Micro Vascular System 

Microscopic capillaries, making up 99% of our circulatory system, are essential for distributing oxygen and nutrients and eliminating toxins from the body. However, when the glycocalyx is impaired, this crucial capillary circulation is reduced, leading to the deterioration of cells, tissues, and organs, which can result in numerous diseases and eventual death.

Early Signs of Endothelial
​Glycocalyx Dysfunction

Glycocalyx Dysfunction Begins a Spiral of Organ Starvation That Can Progress to Several Diseases and Conditions:

Glycocalyx Dysfunction Begins a Spiral of Organ Starvation That Can Progress to Several Diseases and Conditions:

The Good News: Glycocalyx Health Can Be Assessed,  Glycocalyx Function Renewed and Health Restored

Dr. Hans Vink, Director of Advanced Glycocalyx Research at the Glycocalyx Research Institute, has been instrumental in developing and refining GlycoCheck™, a patented, non-invasive, FDA Class 1 medical device that evaluates the health of the glycocalyx.

​Additionally, he and his team have innovated a nutraceutical, proven effective in numerous global clinical studies, for repairing and restoring the function of the glycocalyx, thus significantly aiding in the rejuvenation of health previously compromised by glycocalyx impairment. This nutraceutical's latest iteration is known as ReVasca™.

The Good News: Glycocalyx Health Can Be Assessed,  Glycocalyx Function Renewed and Health Restored

Dr. Hans Vink, Director of Advanced Glycocalyx Research at the Glycocalyx Research Institute, has been instrumental in developing and refining GlycoCheck™, a patented, non-invasive, FDA Class 1 medical device that evaluates the health of the glycocalyx.

Available in Capsules &
Natural Grape Drink Powder

Additionally, he and his team have innovated a nutraceutical, proven effective in numerous global clinical studies, for repairing and restoring the function of the glycocalyx, thus significantly aiding in the rejuvenation of health previously compromised by glycocalyx impairment. This nutraceutical's latest iteration is known as ReVasca™.

The Team Who
Pioneered Glycocalyx Research, Developed the GlycoCheck™ and ReVasca™

Dr. Hans Vink

Robert Long

Co-Founder, Director of Advanced Research

Dr. Vink is a glycocalyx research pioneer, the world’s leading glycocalyx researcher, and the inventor of the GlycoCheck™ testing device. He has published over 250 scholarly papers on the glycocalyx, and his research has been cited in more than 16,000 citations.  Download Dr. Vink's CV

Co-Founder, Director of Nutraceutical Research

Robert Long is a research collaborator with Dr. Vink and the developer of the glycocalyx-regenerating nutraceuticals, the latest refinement being ReVasca™. He formulated the glycocalyx nutraceuticals, and Dr. Vink validated their efficacy with GlycoCheck™..

The Team Who
Pioneered Glycocalyx Research, Developed the GlycoCheck™ and ReVasca™

Dr. Hans Vink

Co-Founder, Director of Advanced Research

Dr. Vink is a glycocalyx research pioneer, the world’s leading glycocalyx researcher, and the inventor of the GlycoCheck™ testing device. He has published over 250 scholarly papers on the glycocalyx, and his research has been cited in more than 16,000 citations.  Download Dr. Vink's CV

Robert Long

Co-Founder, Director of Nutraceutical Research

Robert Long is a research collaborator with Dr. Vink and the developer of the glycocalyx-regenerating nutraceuticals, the latest refinement being ReVasca™. He formulated the glycocalyx nutraceuticals, and Dr. Vink validated their efficacy with GlycoCheck™.

Active Glycocalyx Research 

Currently, over 140 hospitals and universities are conducting glycocalyx research using GlycoCheck™ and the Glycocalyx Research Institute's glycocalyx-restoring nutraceuticals.

The studies are focused on the following health issues: Type 2 Diabetes, Hypertension, Stroke, Kidney Failure, Syndrome X, Sepsis/Septic Shock, Inflammatory Disease, Malaria/Dengue, and Obesity.

The research indicates that glycocalyx health is crucial for overall well-being and in managing diseases related to aging. GlycoCheck™ effectively measures glycocalyx health, and the nutraceuticals developed by Dr. Vink and Robert Long aid in restoring it.

Hospitals and Universities Utilizing the Technology from the Glycocalyx Research Institute

GlycoCheck™ is being used by researchers in hospitals and universities in Africa, Asia, Australia, China, Europe, Japan, Russia, and the United States.

Examples of Glycocalyx-Related Diseases and Conditions Being Researched Using GlycoCheck™

Active Glycocalyx Research 

Currently, over 140 hospitals and universities are conducting glycocalyx research using GlycoCheck™ and the Glycocalyx Research Institute's glycocalyx-restoring nutraceuticals.

The studies are focused on the following health issues: Type 2 Diabetes, Hypertension, Stroke, Kidney Failure, Syndrome X, Sepsis/Septic Shock, Inflammatory Disease, Malaria/Dengue, and Obesity.

The research indicates that glycocalyx health is crucial for overall well-being and in managing diseases related to aging. GlycoCheck™ effectively measures glycocalyx health, and the nutraceuticals developed by Dr. Vink and Robert Long aid in restoring it.

Hospitals and Universities Utilizing the Technology from the Glycocalyx Research Institute

GlycoCheck™ is being used by researchers in hospitals and universities in Africa, Asia, Australia, China, Europe, Japan, Russia, and the United States.

The GlycoCheck™ Technology 

GlycoCheck™ is a non-invasive medical device used to analyze the microvascular health by examining the glycocalyx. The glycocalyx is a microscopic gel-like layer that lines the endothelium (inner wall) of blood vessels and is crucial for vascular health

Administration: To use GlycoCheck™, a specialized video microscope is placed under the tongue. This location is chosen because the capillaries here are close to the surface and easy to access.

FUNCTIONING: Once the microscope is in place, it captures real-time, high-resolution video images of blood flow in the capillaries. These images are then analyzed using advanced software.

Measurement & Analysis: GlycoCheck™ measures the Microvascular Health Score (MVHS), which reflects the condition of the glycocalyx. It does this by assessing factors like the 

perfused boundary region (PBR), which indicates how deep red blood cells can penetrate the glycocalyx. Deeper penetration indicates more glycocalyx damage.

Outcome: By providing a detailed analysis of the glycocalyx and capillary function, GlycoCheck™ helps in the early detection of microvascular issues and guides healthcare professionals in prescribing therapeutic options. 

The GlycoCheck Physicians/
Clinicians
Manual


CUSTOM JAVASCRIPT / HTML
GlycoCheck User Manual

The GlycoCheck™ Technology 

GlycoCheck™ is a non-invasive medical device used to analyze the microvascular health by examining the glycocalyx. The glycocalyx is a microscopic gel-like layer that lines the endothelium (inner wall) of blood vessels and is crucial for vascular health

Administration: To use GlycoCheck™, a specialized video microscope is placed under the tongue. This location is chosen because the capillaries here are close to the surface and easy to access.

FUNCTIONING: Once the microscope is in place, it captures real-time, high-resolution video images of blood flow in the capillaries. These images are then analyzed using advanced software.

Measurement & Analysis: GlycoCheck™ measures the Microvascular Health Score (MVHS), which reflects the condition of the glycocalyx. It does this by assessing factors like the perfused boundary region (PBR), which indicates how deep red blood cells can penetrate the glycocalyx. Deeper penetration indicates more glycocalyx damage.

Outcome: By providing a detailed analysis of the glycocalyx and capillary function, GlycoCheck™ helps in the early detection of microvascular issues and guides healthcare professionals in prescribing therapeutic options. 

The GlycoCheck Physicians/
Clinicians
Manual


CUSTOM JAVASCRIPT / HTML
GlycoCheck User Manual

ReVasca™

                        CAPSULES                                               NATURAL GRAPE DRINK POWDER

ReVasca™ is Dr. Vink's and Robert Long's next-generation nutraceutical designed to support and repair the glycocalyx. It represents the advancement in glycocalyx-focused supplements, succeeding the original formulations known as Arterosil and Endocalyx Pro.*

Composition and Function: ReVasca™ contains a blend of specific nutrients and natural compounds essential for maintaining and repairing the glycocalyx. These ingredients are formulated to work synergistically to support the glycocalyx's structure, thereby enhancing its protective functions. This includes improving the barrier function, which is crucial for regulating the flow of substances between the bloodstream and surrounding tissues*.


Advancements Over Endocalyx Pro™: Having been in use for over 10 years, Endocalyx Pro™. established a foundational revolution in glycocalyx health. However, ReVasca™ incorporates recent advances in nutraceutical technology and new insights from Dr. Hans Vink's research. Dr. Vink believes these developments will make ReVasca™ more effective than its predecessor, offering in his opinion, improved efficacy in supporting and repairing the glycocalyx.

Administration: ReVasca™ is administered orally. It comes in capsules and in a powdered drink formulation that is easy to integrate into daily routines. 

Benefits: By repairing and maintaining the health of the glycocalyx, ReVasca™ helps ensure efficient microcirculation. This, in turn, aids in the optimal delivery of nutrients and oxygen to cells, proper removal of waste products, and overall vascular health, potentially reducing the risk of various microvascular-related conditions.*

In summary, ReVasca™ represents a significant step forward in glycocalyx health, promising to offer enhanced benefits over its predecessors, Arterosil and Endocalyx Pro both formulated by Dr. Hans Vink and Robert Long.*

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ReVasca patient Information

ReVasca™ Physician Monograph

ReVasca™ Patient Information

Order ReVasca™ Today!

ReVasca™

ReVasca™ is Dr. Vink's and Robert Long's next-generation nutraceutical designed to support and repair the glycocalyx. It represents the advancement in glycocalyx-focused supplements, succeeding the original formulations known as Arterosil and Endocalyx Pro.*

Composition and Function: ReVasca™ contains a blend of specific nutrients and natural compounds essential for maintaining and repairing the glycocalyx. These ingredients are formulated to work synergistically to support the glycocalyx's structure, thereby enhancing its protective functions. This includes improving the barrier function, which is crucial for regulating the flow of substances between the bloodstream and surrounding tissues*.


Advancements Over Endocalyx Pro™: Having been in use for over 10 years, Endocalyx Pro™. established a foundational revolution in glycocalyx health. However, ReVasca™ incorporates recent advances in nutraceutical technology and new insights from Dr. Hans Vink's research. Dr. Vink believes these developments will make ReVasca™ more effective than its predecessor, offering in his opinion, improved efficacy in supporting and repairing the glycocalyx.

Administration: ReVasca™ is administered orally. It comes in capsules and in a powdered drink formulation that is easy to integrate into daily routines. 

Benefits: By repairing and maintaining the health of the glycocalyx, ReVasca™ helps ensure efficient microcirculation. This, in turn, aids in the optimal delivery of nutrients and oxygen to cells, proper removal of waste products, and overall vascular health, potentially reducing the risk of various microvascular-related conditions.*

In summary, ReVasca™ represents a significant step forward in glycocalyx health, promising to offer enhanced benefits over its predecessors, Arterosil and Endocalyx Pro both formulated by Dr. Hans Vink and Robert Long.*

ReVasca™ Physician Monograph

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ReVasca™ Patient Information

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ReVasca patient Information

Order ReVasca™ Today!

       ABOUT THE

The Glycocalyx Research Institute, founded in 2012 and led by Dr. Hans Vink and Robert Long, aims to provide education and training on the endothelium glycocalyx and the microvascular system, as well as consult and design glycocalyx and microvascular-based research studies.

The Institute creates and delivers medical devices and nutritional supplements that monitor and support the health and well-being of the endothelial glycocalyx and the microvascular system.

The company’s flagship product is GlycoCheck™, a clinically validated, class-one medical device that enables monitoring and evaluation of the overall strength and dimension of the glycocalyx.

With the revolutionary patented imaging software and hardware system developed by Dr. Hans Vink, healthcare professionals can identify and monitor the contribution of microvascular dysfunction and glycocalyx damage during disease development.

The Glycocalyx Research Institute has also developed a game-changing, proprietary, anti-aging supplement, ReVasca™, which delivers the anti-aging building blocks essential to maintaining a healthy endothelial glycocalyx and capillaries in the microvascular system.

This unique combination of GlycoCheck™ and the ReVasca™ nutraceutical has proven to be successful in restoring, regenerating, and protecting the glycocalyx gel lining of the microvascular system in order to prevent organ starvation.

       ABOUT THE

The Glycocalyx Research Institute, founded in 2012 and led by Dr. Hans Vink and Robert Long, aims to provide education and training on the endothelium glycocalyx and the microvascular system, as well as consult and design glycocalyx and microvascular-based research studies.

The Institute creates and delivers medical devices and nutritional supplements that monitor and support the health and well-being of the endothelial glycocalyx and the microvascular system.

The company’s flagship product is GlycoCheck™, a clinically validated, class-one medical device that enables monitoring and evaluation of the overall strength and dimension of the glycocalyx.

With the revolutionary patented imaging software and hardware system developed by Dr. Hans Vink, healthcare professionals can identify and monitor the contribution of microvascular dysfunction and glycocalyx damage during disease development.

The Glycocalyx Research Institute has also developed a game-changing, proprietary, anti-aging supplement, ReVasca™, which delivers the anti-aging building blocks essential to maintaining a healthy endothelial glycocalyx and capillaries in the microvascular system.

This unique combination of GlycoCheck™ and the ReVasca™ nutraceutical has proven to be successful in restoring, regenerating, and protecting the glycocalyx gel lining of the microvascular system in order to prevent organ starvation.

Physician/Clinician Affiliate Signup

Welcome to our Physician/clinician Affiliate Program! We're excited to have you join our team and help us share our products with your patients. To get started, please follow the two steps below.

Step 1: Submit Proof
of Professional Licensing

To verify your professional status, please send a copy of your license or certification to our dedicated email address:  Click Here to Submit Email 

Step 2: Fill Out the Affiliate Application

Once you've submitted your proof of professional licensing, please complete the affiliate application form by visiting the following link: Affiliate Application Form

What Happens Next?

After we receive and verify your professional licensing and application, you will receive an email with further instructions on how to proceed with the affiliate program. Thank you for your interest in partnering with us. We look forward to a successful collaboration!

Physician/Clinician Affiliate Signup

Welcome to our Physician/clinician Affiliate Program! We're excited to have you join our team and help us share our products with your patients. To get started, please follow the two steps below.

Step 1: Submit Proof of Professional Licensing

Step 2: Fill Out the Affiliate Application

To verify your professional status, please email a copy of your license/ certification or if not licensed, why you would qualify as an affiliate.  Click Here to Submit Email 

Once you've submitted your proof of professional licensing, please complete the affiliate application form by visiting the following link: Affiliate Application Form

What Happens Next?

After we receive and verify your professional licensing and application, you will receive an email with further instructions on how to proceed with the affiliate program. Thank you for your interest in partnering with us. We look forward to a successful collaboration!

Contact Us 

If you are a healthcare professional or university researcher interested in learning more about GlycoCheck™ and Revasca™, please fill out and submit the form below. We will promptly respond to your inquiry.

Contact Us 

If you are a healthcare professional or university researcher interested in learning more about GlycoCheck™ and Revasca™, please fill out and submit the form below. We will promptly respond to your inquiry.

The Glycocalyx Research Institute

OR CALL BOB LONG AT (833) 424-5926 / (833) 42-GLYCO

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The Glycocalyx Research Institute

OR CALL BOB LONG AT (833) 424-5926 / (833) 42-GLYCO

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Copyright 2024 GlycoCalyx Research Institute | All Rights Reserved
Privacy Policy | Terms and Conditions

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.”; and these statemenst do not claim to diagnose, mitigate, treat, cure, or prevent a specific disease or class of diseases.

Copyright 2024 GlycoCalyx Research Institute | All Rights Reserved
Privacy Policy | Terms and Conditions

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.”; and these statemenst do not claim to diagnose, mitigate, treat, cure, or prevent a specific disease or class of diseases.